銆�銆�鍌呴噷钁夎畩鎻涜唱(zh矛)璀滄硶鏄�鍩轰簬闆㈠瓙鍦ㄥ潎鍕荤�佸牬(ch菐ng)涓�鐨勫洖鏃嬮��(y霉n)鍕�(d貌ng)锛屼緥瀛愮殑鍥炴棆闋荤巼銆佸崐寰�銆侀�熺巼鍜岃兘閲忔槸闆㈠瓙璩�(zh矛)閲忓拰闆㈠瓙闆昏嵎鍙婄�佸��(ch菐ng)寮�(qi谩ng)搴︾殑鍑芥暩(sh霉)銆傞�氶亷(gu貌)涓�鍊�(g猫)绌洪枔鍧囧嫽鐨勫皠闋诲牬(ch菐ng)锛堟縺鐧�(f膩)闆诲牬(ch菐ng)锛夌殑浣滅敤锛岀暥(d膩ng)闆㈠瓙鐨勫洖鏃嬮牷鐜囪垏婵�鐧�(f膩)灏勯牷鍫�(ch菐ng)闋荤巼鐩稿悓锛堝叡鎸�锛夋��(sh铆)锛岄洟瀛愬皣鍚岀浉浣嶅姞閫熻嚦涓�杓冨ぇ鐨勫崐寰戝洖鏃�锛屽緸鑰岀敘(ch菐n)鐢熷彲琚�鎺ュ彈鐨勮薄闆绘祦淇¤��(h脿o)銆傚倕閲岃憠璁婃彌娉曟墍閲囩敤鐨勫皠闋昏寖鍦嶈�嗚搵浜嗘�叉脯(c猫)瀹氱殑璩�(zh矛)閲忚寖鍦�锛屾墍鏈夐洟瀛愬悓鏅�(sh铆)琚�婵�鐧�(f膩)锛屾墍妾㈡脯(c猫)鐨勪俊铏�(h脿o)缍�(j墨ng)绂忓埄钁夎畩鎻涜檿鐞�锛岃綁(zhu菐n)璁�?y艒u)姗榺(zh矛)璀滃湒銆�

銆�銆�鏈�鏃╃殑ICR MS鍙�杩芥函鍒癊.O.Lawrence's鍥炴棆銆�1950骞达紝Sommer.Thomas鍜孒ipple鐮斿埗浜嗚嚭(t谩i)鏈夊��(sh铆)鐢ㄥ児(ji脿)鍊肩殑鍥炴棆璩�(zh矛)璀滃剙銆傝�岀湡姝ｄ娇闆㈠瓙鍥炴棆鍏辨尟璩�(zh矛)璀滃剙鐧�(f膩)灞曞彶缈婚枊(k膩i)宥勬柊涓�闋�(y猫)鐨勪簨1974骞碝arshall鍜孋omisarow鎶奆T鏂规硶鐢ㄤ簬铏曠悊ICR鏁�(sh霉)鎿�(j霉)銆傞毃鍚�锛屽倕閲岃憠璁婃彌闆㈠瓙鍥炴棆鍏辨尟璩�(zh矛)璀滃剙鐨勫剙鍣ㄨō(sh猫)瑷�(j矛)鍜屾噳(y墨ng)鐢ㄩ兘寰楀埌浜嗚繀閫熺殑鐧�(f膩)灞�锛屽倕閲岃憠璁婃彌璩�(zh矛)璀滃剙鏄�涓�绋�楂樺垎杈ㄧ巼鐨勮��(zh矛)璀滃剙锛屾脯(c猫)瀹氱殑婧�(zh菙n)纰哄害楂�锛屾暩(sh霉)鎿�(j霉)閲囬泦閫熷害蹇�锛屽彲浠ヨ垏澶氱ó闆㈠瓙鍖栨柟寮忛�ｆ帴锛屽彲閫�(j矛n)琛屽�氱��(j铆)璩�(zh矛)璀淢S鐨勬�㈡��(c猫)锛屽湪鍖栧悎鐗╃浉灏�(du矛)鍒嗗瓙璩�(zh矛)閲忔脯(c猫)瀹�銆佺祼(ji茅)妲�(g貌u)淇℃伅鐛插彇鍙婂弽鎳�(y墨ng)姗�(j墨)鐞嗙殑鐮旂┒绛夋柟闈㈢櫦(f膩)鎻�钁楅噸瑕佷綔鐢�銆傝繎骞翠締(l谩i)鑸囧熀璩�(zh矛)杓斿姪婵�鍏夎В鍚搁洟瀛愬寲MALDI鍙婇浕鍣撮湩闆㈠瓙鍖朎SI鑱�(li谩n)鐢�锛屾垚鐐虹敓鐗╁ぇ鍒嗗瓙鐮旂┒涓�涓�鍊�(g猫)涓嶅彲澶氬緱鐨勫伐鍏�銆�